Endocrine Abstracts

About 19 year-old, female, presented with sweating in both arms for many years. The sweating has progressively got worse over the last several years. Occasionally, her feet and lower back can also be affected. They do not tend to occur particularly at night and have no association with alcohol, meals or fasting. Her periods are regular. She does not have any associated symptoms such as headache and visual disturbance.She has no significant family history...

A 56 years old lady was referred to our endocrine service for further management of levothyroxine replacement. She was diagnosed with Graves’ disease 26 years ago and underwent thyroidectomy as definite treatment. Post-operatively, she was commenced on 100mcg of levothyroxine and continued to have regular follow up with her GP. It was noted that her levothyroxine dose had to be reduced to 50 mcg daily over a period of 10 years due to persistently suppressed TSH levels wit...

A sixty-four year old man presented for investigation of mild hypercalcaemia (2.68 mmol/L) incidentally discovered during preoperative workup for elective removal of a testicular cyst. He had no family history of renal stones. His younger brother had undergone a parathyroidectomy at the age of 60. His father died in a road traffic accident aged 54. His mother was 84 and had no history of endocrine disease. Urine calcium:creatinine excretion ratio was 0.0207, excluding familial...

Introduction: Gastrinoma is a rare neuroendocrine tumor and associated with liver metastasis in 20–40% of cases. We present a rare case report of a patient with stable liver metastasis due to gastrinoma for more than 35 years.Case report: A 49 year old male is currently on our regular clinic follow up for the liver metastasis due to gastrinoma. His past history includes open laparotomy and resection of gastrinoma (Proven histologically) at the age o...

We present two patients who have increased uptake in the thyroid on PET imaging.Mrs AN is a 76-year-old woman with hypertension, atrial fibrillation, deep vein thrombosis and primary autoimmune hypothyroidism with positive TPO antibodies on thyroxine. When abroad she had a carotid USS which discovered a thyroid nodule. Referred to us she was euthyroid with an USS finding of a 5 mm calcified nodule with no vascularity in the right thyroid. She had a FNA i...

A 77 year old man with a background of Crohns disease requiring ileostomy, pernicious anaemia and hypertension, presented with a 4month history of dysphagia to solids, hoarseness of voice, anorexia and marked weight loss of 30 kg. He was initially referred to gastroenterology, who performed an endoscopy which was normal. Subsequently he was referred to the ENT and speech and language therapy departments. A video fluoroscopy confirmed severe oropharyngeal dysphagia with effortf...

A 27 year old lady with a background of Langerhans cell histiocytosis (LCH) presented to endocrinology clinic for investigation of thyrotoxicosis. At the age of three years old, she presented with a rash on her forehead, which on biopsy revealed Langerhans cell histiocytosis. She was also noted to have symptoms consistent with diabetes insipidus, for which she remains on desmopressin therapy. At the age of six she received pituitary radiotherapy and 6 years ago developed secon...

A 60year old gentleman was referred to endocrine team with new onset hyperthyroidism. He had developed tubulointerstitial nephritis secondary to carbamazepine resulting in ESRF 3 years previously. Four months prior to presentation he received a live-unrelated renal transplant including a single dose of Alemtuzamab post-operatively for induction of immunosuppression. Thereafter his immunosuppression was maintained with tacrolimus. Other medical history included bipolar disorder...

Background: Chromaffin cell tumours are rare but potentially curable endocrine tumours. These tumours may be sporadic or familial in nature. Biochemical tests are normally performed initially, followed by radiological investigation.Aim: To assess the correlation of biochemical and radiological investigations with histologically proven chromaffin-cell tumours in patients with sporadic and familial disease.Methods: We retrospectively...

A 19-year-old man was referred to Endocrinology Clinic with a minimally raised calcitonin level. He had a past history of primary hyperparathyroidism resulting in renal colic aged 17 years, and underwent three gland parathyroidectomy aged 18 years. Histology demonstrated a single right lower parathyroid adenoma with normal thyroid biopsy. He has no family history of endocrine disease and is a non-smoker. His calcium has remained normal since with detectable PTH. Over 5 years t...